Incazelo yesichazamazwi yetemu elithi "Immunoglobulin E" noma "IgE" iwuhlobo lwephrotheni, olwaziwa nangokuthi i-antibody, edlala indima ebalulekile ekuphenduleni kwesimiso somzimba sokuzivikela ezifweni kokungezwani nokudla kanye nezifo eziyizimuncagazi. I-IgE ikhiqizwa amangqamuzana ayisipesheli amasosha omzimba aziwa ngokuthi amaseli e-plasma futhi atholakala egazini nasezicutshini zomzimba.Lapho i-allergen, njenge-pollen noma uboya besilwane, ingena emzimbeni, iqala ukukhiqizwa Amasosha omzimba e-IgE. Lawa ma-antibodies abopha kuma-receptors kuma-mast cell kanye nama-basophil, okuyizinhlobo zamaseli omzimba akhulula i-histamine namanye amakhemikhali ekuphenduleni izinto ezingezwani nomzimba. Lokhu kukhishwa kwe-histamine kubangela izimpawu zokungezwani komzimba, njengokuluma, ukuvuvuka, nokuvuvukala.Ngaphezu kwendima yayo ekungezwani komzimba, i-IgE iphinde ibe neqhaza ekuvikeleni umzimba ezifweni ezibangelwa amagciwane, njengalezo ezibangelwa helminths (izikelemu). Amasosha omzimba e-IgE abopha kulawa magciwane futhi enze amaseli omzimba asebenze ukuze awabhubhise.