South Carolina jiha ce dake a yankin kudu maso gabashin Amurka. Tana iyaka da Arewacin Carolina zuwa arewa, Jojiya a kudu da yamma, da Tekun Atlantika daga gabas. Babban birnin jihar shine Columbia kuma birni mafi girma shine Charleston. Sunan "South Carolina" an yi imanin ya samo asali ne daga Sarki Charles na farko na Ingila, wanda ya sanya wa yankin suna domin girmama mahaifinsa, Sarki Charles I.