Ma'anar ƙamus na kalmar "matsakaicin haɗakar immunodeficiency" (SCID) cuta ce mai wuyar gaske, cuta ta kwayoyin halitta wacce ke shafar tsarin garkuwar jiki, wanda ke haifar da nakasu mai tsanani ko rashin ƙwayoyin T da ƙwayoyin B. SCID yana sa mutane su zama masu saurin kamuwa da cututtuka, gami da waɗanda ke haifar da ƙwayoyin cuta, ƙwayoyin cuta, da fungi, kuma galibi suna haifar da yanayi masu haɗari. Mutanen da ke da SCID yawanci suna buƙatar jiyya mai gudana, kamar maganin maye gurbin immunoglobulin, maganin rigakafi, da magungunan rigakafin fungal. A wasu lokuta, dashen kasusuwa ko kuma dashen sel na iya zama dole don maye gurbin sel masu lahani na rigakafi.