Santo Domingo babban birni ne kuma birni mafi girma a Jamhuriyar Dominican, wanda ke bakin tekun kudancin tsibirin Hispaniola a cikin Tekun Caribbean. Bartholomew Columbus, ɗan'uwan Christopher Columbus ne ya kafa shi a cikin 1496, kuma shine farkon mazaunin Turai a cikin Amurka. Sunan "Santo Domingo" ya samo asali ne daga Saint Dominic, wanda ya kafa Dokar Dominican na Cocin Katolika, wanda ya taka muhimmiyar rawa a tarihi da al'adun birnin.