Santiago de Cuba suna ne da ya dace wanda ke nufin wani birni da ke kudu maso gabashin Cuba. Sunan "Santiago" ya samo asali ne daga sunan Mutanen Espanya na Saint James, wanda shine majibincin Spain. "Cuba" shine sunan ƙasar da Santiago de Cuba yake. Saboda haka, ana iya fassara Santiago de Cuba zuwa "Saint James na Cuba" ko "St. James's Cuba" a Turanci.
