Ma'anar ƙamus na kalmar "polygenic cuta" cuta ce da ke haifar da haɗin gwiwar kwayoyin halitta da yawa, sabanin cutar da ke haifar da kwayar halitta guda ɗaya. A cikin cututtuka na polygenic, bambance-bambancen kwayoyin halitta masu yawa, kowannensu yana da ƙananan tasiri, yana taimakawa wajen haɓakar cutar gaba ɗaya. Misalan cututtukan polygenic sun haɗa da nau'in ciwon sukari na 2, hauhawar jini, da wasu nau'ikan ciwon daji. Wadannan cututtukan suna tasiri ta hanyar haɗuwa da kwayoyin halitta da abubuwan muhalli, kuma haɗarinsu na iya canzawa ta hanyar sauye-sauyen salon rayuwa kamar abinci da motsa jiki.