Kalmar "manic depression" wani tsohon lokaci ne na rashin lafiya na biyu, rashin lafiyar tabin hankali da ke tattare da yanayin sauye-sauyen yanayi wanda ke tashi daga matsananciyar yanayi (Mania ko hypomania) zuwa matsananciyar kasala (damuwa). A lokacin tashin hankali, mutum na iya jin euphoric, fushi, ko wuce gona da iri, yana da tunanin tsere, kuma ya shiga cikin halayen haɗari. A lokacin abubuwan damuwa, mutum na iya jin bakin ciki, rashin bege, kuma ya rasa sha'awar ayyukan da ya taɓa jin daɗi. Kalmar "manic depression" ba a cika amfani da ita a yau ba kuma an maye gurbinta da kalmar "bipolar disorder."