Yaƙin Macedonia yana nufin jerin tashe-tashen hankula da suka faru a ƙarni na 3 da na 2 BC tsakanin garuruwa da masarautu dabam-dabam na ƙasar Girka, da kuma daular Macedon, wadda daular Antigonid ke mulki. An gwabza waɗannan yaƙe-yaƙe ne don mallakar duniyar Girka da kuma yankunan da Alexander the Great ya ci, waɗanda suka haɗa da Macedon, Girka, Asiya Ƙarama, Masar, da kuma wasu sassan Indiya. Yaƙe-yaƙe na Macedonia a ƙarshe sun haifar da shan kashi na Macedon da kuma kafa Roma a matsayin mai iko a duniyar Bahar Rum.