Knoxville suna ne da ke nufin wani birni a gabashin yankin Tennessee a Amurka. Birnin shi ne na uku mafi girma a cikin jihar kuma yana can a gindin tsaunin Great Smoky Mountains. An san ta don ɗimbin tarihinta, abubuwan jan hankali na al'adu, nishaɗin waje, da tattalin arziki iri-iri. Sunan "Knoxville" ya fito ne daga Henry Knox, janar a yakin juyin juya halin Amurka wanda daga baya ya zama sakataren yaki na farko a karkashin Shugaba George Washington.