Ma'anar ƙamus na kalmar isomerization shine tsarin juya isomer ɗaya zuwa wani, musamman ta hanyar sake tsara kwayoyin halitta ko ƙungiyoyin atom a cikin kwayoyin halitta. Isomers kwayoyin halitta ne da suke da tsarin kwayoyin halitta iri daya amma tsarin tsarin kwayoyin halittarsu daban-daban. Isomerization ya haɗa da sake tsara kwayoyin halitta a cikin kwayar halitta don samar da wani isomer daban yayin kiyaye tsarin kwayoyin halitta iri ɗaya. Ana amfani da wannan tsari sau da yawa a cikin halayen sinadarai don samar da takamaiman samfura ko don canza wani abu zuwa wani tare da kaddarorin daban-daban.