Ma'anar ƙamus na kalmar "granulomatous" yana da alaƙa da ko siffa ta samuwar granulomas, waɗanda ƙananan nodules ne na ƙwayoyin rigakafi waɗanda ke haifar da amsawar kumburi ko kamuwa da cuta. Granulomas na iya samuwa a cikin gabobin jiki daban-daban da kyallen takarda na jiki kuma sun ƙunshi ƙwayoyin rigakafi, irin su macrophages, lymphocytes, da ƙananan ƙwayoyin cuta. Ana danganta kumburin granulomatous sau da yawa tare da wasu cututtuka masu yaduwa, kamar su tarin fuka, da kuma wasu cututtuka na autoimmune.