Kalmar "gabon ƙarshe" yawanci yana nufin makoma ta ƙarshe ko manufa ta takamaiman siginar jijiya ko hormonal a cikin jiki. A cikin magani, ana amfani da kalmar sau da yawa don bayyana takamaiman kyallen takarda ko gabobin da wani cuta ko yanayi ya shafa. Misali, a cikin ciwon sukari, ''karshen gabobi'' da aka fi shafa sun hada da idanu, kodan, da jijiyoyi. Ainihin, "Gaba ta ƙarshe" ita ce ta ƙarshe mai karɓar siginar ilimin lissafi, don haka shine wurin da sakamakon sakamako ko tasiri.