Jami'ar Duke jami'ar bincike ce mai zaman kanta da ke Durham, North Carolina, Amurka. An kafa shi a cikin 1838 a matsayin Kwalejin Trinity kuma daga baya aka canza sunan Jami'ar Duke a 1924, bayan dangin Duke, waɗanda suka ba da babbar baiwa ga cibiyar. An san jami'ar don shirye-shiryenta na ilimi, bincike, da ƙungiyoyin motsa jiki, kuma ana ba da lambarta akai-akai a matsayin ɗaya daga cikin manyan jami'o'i a Amurka.