Ma'anar ƙamus na kalmar depolarization shine tsari na rage ko kawar da polarization na barbashi ko tsarin. A cikin ilimin lissafi, depolarization yana nufin canji a cikin cajin wutar lantarki na kwayar halitta daga mummunan yanayi zuwa yanayi mai kyau, wanda ke faruwa a lokacin da aka yi cajin ions mai kyau kamar sodium shiga cikin tantanin halitta. Depolarization shine maɓalli mai mahimmanci a cikin tsararrun jijiyoyi da tsoka, kuma yana taka muhimmiyar rawa a yawancin tsarin ilimin lissafi kamar watsawar synaptic da aikin zuciya.