Ma'anar ƙamus na kalmar decarboxylase wani enzyme ne wanda ke haifar da cire ƙungiyar carboxyl (-COOH) daga kwayoyin halitta, yawanci yana haifar da sakin carbon dioxide (CO2). Decarboxylases suna da mahimmanci a hanyoyi daban-daban na biochemical kuma ana samun su a cikin kwayoyin prokaryotic da eukaryotic. Wasu misalan decarboxylases sun haɗa da amino acid decarboxylases, waɗanda ke haifar da cire ƙungiyar carboxyl daga amino acid, da pyruvate decarboxylase, wanda ke haifar da cire ƙungiyar carboxyl daga pyruvate don samar da acetaldehyde.