Ma'anar ƙamus na kalmar "makafin maƙarƙashiya" wani yanayi ne a cikin dabbobi, musamman ma dawakai, inda suke samun rashin daidaituwa, daidaitawa, da sarrafa motsin su. Sau da yawa yana haifar da ciwon jijiya ko cututtuka kuma yana iya haifar da rashin tunani, tuntuɓe, da faɗuwa. A cikin ɗan adam, kalmar "makafin maƙarƙashiya" na iya nufin yanayin tashin hankali ko rudani, sau da yawa saboda yawan shan barasa.