Agammaglobulinemia cuta ce ta rashin lafiya ko ƙarancin matakan immunoglobulins ko ƙwayoyin rigakafi a cikin jini, wanda ke sa mutum ya iya kamuwa da cututtuka masu yawa. Wata cuta ce da ba kasafai ake samun ta ba wacce ke shafar tsarin garkuwar jiki, musamman ikon samar da kwayoyin rigakafin da ke da muhimmanci wajen yakar cututtuka da kwayoyin cuta da kwayoyin cuta ke haifarwa. Kalmar "agammaglobulinemia" ta samo asali ne daga kalmomin Helenanci "a-" ma'ana "ba tare da," "gamma" yana nufin immunoglobulins, da "globulinemia" yana nufin kasancewar sunadaran globulin a cikin jini.