Ƙungiyar acyl ƙungiya ce mai aiki a cikin sinadarai na halitta wanda ya ƙunshi ƙungiyar carbonyl (C=O) da ke haɗe zuwa ƙungiyar alkyl ko aryl. Ana iya wakilta shi azaman RCO-, inda R shine ƙungiyar alkyl ko aryl. Ƙungiyar acyl sau da yawa ana samun su a cikin kwayoyin halitta irin su acetic acid, acetylcholine, da acetylsalicylic acid (aspirin), kuma yana da mahimmanci wajen samar da mahadi masu yawa na biochemical kamar fatty acid, glycerides, da phospholipids.