Kalmar "Cooley's anemia" wani lokaci ne da ya wuce na rashin lafiyar jini da ake kira beta-thalassaemia major. Beta-thalassaemia rukuni ne na cututtukan jini da aka gada wanda ke shafar samar da haemoglobin, furotin da ake samu a cikin jajayen ƙwayoyin jini wanda ke ɗauke da iskar oxygen a cikin jiki. Mutanen da ke da beta-thalassaemia suna da raguwar ƙarfin samar da haemoglobin, wanda ke haifar da anemia, ko ƙarancin jan jini. rashin lafiya, kuma yawanci ana gano shi a lokacin ƙuruciya. Yana da ƙarancin matakin haemoglobin, wanda ke haifar da anemia mai tsanani, kuma yana buƙatar ƙarin jini na tsawon rai don sarrafa yanayin. Idan ba tare da magani ba, beta-thalassemia major na iya yin barazana ga rayuwa.