TV series example of the word

The Big Bang Theory Season 3, Episode 11
...with his dating a woman whose most significant achievement...

The Big Bang Theory Season 2, Episode 6
...to make any significant contribution to physics played a trick on you.

The Big Bang Theory Season 10, Episode 7
Gentlemen, please! This is a significant decision.

Game of Thrones Season 3, Episode 3
Only my life. Not all that significant, I'm afraid.

Game of Thrones Season 5, Episode 7
it will represent a significant rise in your station.