(1) The Smallpox virus, or variola , has been wreaking havoc across the globe for thousands of years.

(2) Stocks of variola , the virus that causes the disease, remained in two locations - one in the United States and one in Russia.

(3) It suggested that immunizing humans against smallpox might protect them against genetically engineered variola as well.

(4) Other viruses in this group that can cause infection in humans include variola , vaccinia (used in smallpox vaccine), and cowpox viruses.

(5) No current technology is capable of discriminating variola from vaccinia (ie, the acute infectious disease caused by smallpox vaccination).

(6) In order to determine this, a non-vaccinated child was inoculated with the serous fluid obtained from these variolous papules, and the result was a generalized, confluent small-pox.

(7) In about 1721, local minister Cotton Mather - perhaps best known for his role in the witchcraft trials - was among the first in America to experiment with variolous inoculation for smallpox.

(8) Seven made rapid recoveries with minimal scarring, one showed no benefit, and one died (apparently of variolar pneumonia).

(9) It was found that up to a certain point the same series of changes which the matter undergoes when in contact with the patient's body in the variolous vesicle would take place in a sealed tube in his room.

(10) One of them, who had travelled in a neighboring district, where there were some cases of small-pox, complained of a little fever, which was followed by slight eruptions, but so unlike true variolous pustules, that I treated the matter very lightly.

(11) During the time she remained in the infected room, variolous matter was inserted into both her arms, but without any further effect than in the preceding case.